Paris- Cardiovascular Research Center - Inserm U970
Team 11 – Inflammatory vascular remodeling and microenvironmental homeostasis
56 rue Leblanc, 75015 Paris
Tel: 0033 1 53 98 80 11
e-mail : firstname.lastname@example.org
The research team "Inflammatory vascular remodeling and microenvironmental homeostasis" is looking for a postdoctoral fellow to lead a research project on myeloid cell-driven angiogenesis during tumor relapse after chemotherapy using different mouse models of cancer. This postdoctoral position will be based in PARis Cardiovascular research Center. It will start as soon as possible and will be initially limited to 12 month with a possible extension. There is no nationality restriction. The working language will be French and/or English.
In the context of chemotherapeutic treatment, it is becoming increasingly recognized that the architecture of the tumor vasculature and its functionality, rather than blood vessel counts, determine the therapeutic outcome by controlling drug delivery as well as microenvironmental conditions. In most tumors, blood vessels significantly differ from normal vascular networks and are characterized by inefficient blood supply despite high vasculature density. Hence, a better understanding of mechanisms involved in the regulation of drug sensitivity is indispensable for improved cancer treatments. Vascular Endothelial Growth Factor (VEGF) is a major angiogenic factor and we have shown that deletion of VEGF in tumor infiltrating myeloid cells leads to improved functionality of intratumoral blood vessels, alleviated tumor hypoxia and increased susceptibility to cytotoxic agents in mouse models of cancer. However, most of the studies focus on the initial response of tumors to therapy, and preclinical studies on avoidance of tumor relapse are lacking... (lire la suite)
Comme tous les ans, la SCMC attribuera un prix d’une valeur de 1000 euros à une personne dont les travaux contribueront à développer les connaissances sur le cerveau et les maladies cérébrovasculaires.
Conditions de candidature :
Avoir moins de 35 ans
Etre membre de la SCMC, à jour de sa cotisation
Thèse soutenue depuis moins de deux ans et au plus tard le 31/12/2013
University of Sheffield UK - Department of Neuroscience
Faculty: Faculty of Medicine, Dentistry and Health Contract Type: Fixed-term for three years Working Pattern: Full Time Salary: Grade 7, £28,685 to £36,298 per annum with potential to progress to £39,649 Job Reference Number: UOS007813
We are seeking a highly motivated scientist to carry out research projects in Translational Cerebrovascular Disease. We are exploring innovative cerebroprotection strategies with the central purpose of developing novel clinical therapies for devastating vascular diseases of the brain. You will have an excellent research and publication track record and will contribute to the work of an internationally recognised research group. You must possess excellent organisation skills and the ability to interact well within a group. You should be qualified to PhD level (or equivalent) in Neuroscience or Biological Sciences and have experience and interest in translational research. You will use in vivo and in vitro approaches to determine the molecular and cellular pathways that underlie preconditioning and cerebroprotection in the brain. We have already identified candidate pathways but these require further elucidation. After elucidation, pharmacological manipulation of the most ‘promising’ pathway would be the next step with the aim of developing a clinical therapy. Expertise with cell culture (neuronal and astrocytic) and focal ischaemia models of stroke would be a considerable advantage To apply for this role, please contact Professor Majid
Closing Date: 9 October 2013
Professor Arshad Majid email@example.com Professor of Cerebrovascular Neurology Sheffield Institute for Translational Neuroscience (SITraN) University of Sheffield 385A Glossop Road SHEFFIELD S10 2HQ
We offer thirteen PhD positions (Early Stage Researcher) for three years to undertake research in neuroinflammation. This research is supported by the Marie Curie Initial Training Network (ITN) “nEUROinflammation” within the EU Seventh Framework Programme for Research and Technological Development (2007-2013). The scientific goal of nEUROinflammation is to investigate inflammatory mechanisms in stroke and multiple sclerosis with a special focus on bone-marrow derived macrophages, dendritic cells, the endothelium, and microglia. A unique feature of our consortium is to combine stroke and MS research in order to release synergies between the fields and to provide PhD students with a comprehensive picture of neuroinflammation. By employing a range of experimental and translational techniques, this ITN aims at one goal: to modulate basic neuroinflammatory mechanisms for the treatment of neurological diseases.
The PhD students will be hosted by 16 academic or industrial partner organizations in Germany, Italy, France, Spain, Finland, Poland, Netherlands, and Switzerland. For additional job details and the main activities in each project of nEUROinflammation, please follow the link www.neuroinflammation.eu... (lire la suite)