Stages & emplois

POST-DOCTORAL POSITION - Inflammatory vascular remodeling and microenvironmental homeostasis


Dr. Christian Stockmann, MD,

Paris- Cardiovascular Research Center - Inserm U970

Team 11 – Inflammatory vascular remodeling and microenvironmental homeostasis 

56 rue Leblanc, 75015 Paris

Tel: 0033 1 53 98 80 11

e-mail : 



The research team "Inflammatory vascular remodeling and microenvironmental homeostasis" is looking for a postdoctoral fellow to lead a research project on myeloid cell-driven angiogenesis during tumor relapse after chemotherapy using different mouse models of cancer. This postdoctoral position will be based in PARis Cardiovascular research Center. It will start as soon as possible and will be initially limited to 12 month with a possible extension. There is no nationality restriction. The working language will be French and/or English.


In the context of chemotherapeutic treatment, it is becoming increasingly recognized that the architecture of the tumor vasculature and its functionality, rather than blood vessel counts, determine the therapeutic outcome by controlling drug delivery as well as microenvironmental conditions. In most tumors,  blood vessels significantly differ from normal vascular networks and are characterized by inefficient blood supply despite high vasculature density. Hence, a better understanding of mechanisms involved in the regulation of drug sensitivity is indispensable for improved cancer treatments. Vascular Endothelial Growth Factor (VEGF) is a major angiogenic factor and we have shown that deletion of VEGF in tumor infiltrating myeloid cells leads to improved functionality of intratumoral blood vessels, alleviated tumor hypoxia and increased susceptibility to cytotoxic agents in mouse models of cancer. However, most of the studies focus on the initial response of tumors to therapy, and preclinical studies on avoidance of tumor relapse are lacking... (lire la suite)

Post-doctoral Research Associate

University of Sheffield UK - Department of Neuroscience

Faculty: Faculty of Medicine, Dentistry and Health
Contract Type: Fixed-term for three years
Working Pattern: Full Time
Salary: Grade 7, £28,685 to £36,298 per annum with potential to progress to £39,649
Job Reference Number: UOS007813
We are seeking a highly motivated scientist to carry out research projects in Translational Cerebrovascular Disease. We are exploring innovative cerebroprotection strategies with the central purpose of developing novel clinical therapies for devastating vascular diseases of the brain. You will have an excellent research and publication track record and will contribute to the work of an internationally recognised research group. You must possess excellent organisation skills and the ability to interact well within a group. You should be qualified to PhD level (or equivalent) in Neuroscience or Biological Sciences and have experience and interest in translational research.
You will use in vivo and in vitro approaches to determine the molecular and cellular pathways that underlie preconditioning and cerebroprotection in the brain. We have already identified candidate pathways but these require further elucidation. After elucidation, pharmacological manipulation of the most ‘promising’ pathway would be the next step with the aim of developing a clinical therapy.
Expertise with cell culture (neuronal and astrocytic) and focal ischaemia models of stroke would be a considerable advantage
To apply for this role, please contact Professor Majid
Closing Date: 9 October 2013
Professor Arshad Majid
Professor of Cerebrovascular Neurology 
Sheffield Institute for Translational Neuroscience (SITraN)
University of Sheffield
385A Glossop Road

Postdoctoral Position Available at Loma Linda University, Departments of Pediatrics and Physiology, California

A postdoctoral position is available in the laboratory of Jerome Badaut, Ph.D., interested in the neurovascular and blood-brain barrier dysfunctions after brain injuries. This position is part of a NIH funded project involving the potential therapeutic effects of a JNK inhibitor and silencing RNA targeting Aquaporin 4 in juvenile traumatic brain injury. The ideal candidate would be a recent Ph.D. or M.D./Ph.D. with a background in rat or mice TBI model surgeries and/or some experience with immunohistochemistry and western blot. The candidate will also be expected to work effectively with graduate and undergraduate students. Detailed information can be found at

Interested scientists should send a CV, list of references, and cover letter to

Summer School - Experimental models of brain diseases

L’unité Inserm U919  «Sérine protéases et  physiopathologie  de  l’Unité Neurovasculaire» et l’équipe CERVOxy de l’UMR CNRS 6232 «Hypoxie et physiopathologie cérébrovasculaire» organisent, avec le soutien du projet TC2N, une Ecole d’Eté intitulée «Experimental models of brain diseases: stroke, glioma and multiple sclerosis» du 3 au 6 avril 2012 au centre Cycéron à Caen.

L’objectif de cette Ecole théorique et pratique est de présenter certains modèles animaux utilisés en recherche dans le domaine de l’ischémie cérébrale, des tumeurs cérébrales et de la sclérose en plaque. Elle permettra aux étudiants, chercheurs et techniciens de se familiariser avec un ou plusieurs modèles de leur choix et d’acquérir des techniques d’évaluation des atteintes cérébrales dans ces modèles. 

 .. (lire la suite)

Voir le document lié

Allocation doctorale à Caen

Une allocation doctorale du Ministère de la recherche fera l’objet d’un concours au sein de l’Ecole doctorale EdnBise.

Le candidat sélectionné rejoindra, en septembre 2011, l’équipe CERVOxy “Hypoxie et Physiopathologie Cérébrovasculaire” de l’UMR 6232 hébergée à Cycéron, centre de d’imagerie biomédicale permettant l’accès à des techniques d’imagerie de pointe telles que la TEP et l’IRM au niveau clinique et préclinique.

Les équipes de l’UMR 6232 s’intéresse aux mécanismes moléculaires, cellulaires et physiopathologiques sous-jacents à la mort neuronale dans plusieurs maladies cérébrales et plus particulièrement l’accident vasculaire cérébral. Les approches de recherche employées sont exceptionnelles allant de la biologie moléculaire à la neuroimagerie dans des modèles intégrés.

Le niveau académique du candidat est un facteur déterminant dans l’attribution de l’allocation... (lire la suite)

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